Evidence map›Paper›PMID 41293654›Full record

ArticleJIMD reports2025

Elevated Transaminases: Does It Always Warrant a Liver Biopsy? Lessons Learned From Pompe Disease.

Alicia Khazzeka, Rebecca L Koch, Jeong-A Lim, Jeremy D Ward, Jessica Doxey, William R Jeck, Priya S Kishnani

Abstract read
In one paragraph

Article in JIMD reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alicia KhazzekaDivision of Medical Genetics, Department of Pediatrics Duke University School of Medicine Durham North Carolina USA.
Rebecca L KochDivision of Medical Genetics, Department of Pediatrics Duke University School of Medicine Durham North Carolina USA.
Jeong-A LimDivision of Medical Genetics, Department of Pediatrics Duke University School of Medicine Durham North Carolina USA.ORCID https://orcid.org/0000-0002-4373-4800
Jeremy D WardDepartment of Pathology Duke University Durham North Carolina USA.
Jessica DoxeyDivision of Medical Genetics, Department of Pediatrics Duke University School of Medicine Durham North Carolina USA.
William R JeckDepartment of Pathology Duke University Durham North Carolina USA.
Priya S KishnaniDivision of Medical Genetics, Department of Pediatrics Duke University School of Medicine Durham North Carolina USA.ORCID https://orcid.org/0000-0001-8251-909X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pompe disease (PD) is an autosomal recessive disorder caused by pathogenic variants in

Indexed as

creatine kinaseGAA enzymegene sequencingliver biopsyPompe diseasetransaminases

Identifiers

PMID41293654
PMCPMC12643788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.