ArticleJournal of inflammation research2025
PCK2, a SASP-Associated Gene, Serves as an Independent Prognostic Indicator in Diffuse Large B-Cell Lymphoma.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diffuse large B-cell lymphoma (DLBCL) is characterised by substantial heterogeneity in phenotype and genetics. Recent studies have demonstrated that senescence-associated secretory phenotype (SASP) is both a tumor suppressor and a promoter of tumorigenesis and progression. However, reports on the effects of SASP on DLBCL remain limited. This study aimed to identify the SASP-related indicator of DLBCL, thereby providing new insights into the pathology of DLBCL. Methods: Differential analysis and weighted co-expression network analysis (WGCNA) were applied to identify differentially expressed genes (DEGs) and key gene modules of DLBCL. Univariate Cox regression analysis was employed to identify SASP-related genes that serve as independent risk factors for DLBCL prognosis. Overlapped among three methods to obtain the hub gene and explore its potential mechanisms in DLBCL. The association between Results: In this study, through integrated bioinformatics methods, Conclusion: As a SASP-related gene,
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