Evidence map›Paper›PMID 41293620›Full record

ArticleFrontiers in cardiovascular medicine2025

Changes in patient characteristics and procedural measures over a 10-year period in aortic valve-in-valve procedures for degenerated surgical bioprostheses.

Tim Knochenhauer, Till J Demal, Oliver D Bhadra, Sebastian Ludwig, Nils Arne Sörensen, Ina von der Heide, Laura Hannen, David Grundmann, Lisa Voigtländer-Buschmann, Lara Waldschmidt and 7 more

Abstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Tim KnochenhauerDepartment of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Till J DemalDepartment of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Oliver D BhadraDepartment of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Sebastian LudwigDepartment of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Nils Arne SörensenDepartment of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Ina von der HeideDepartment of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Laura HannenDepartment of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.
David GrundmannDepartment of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Lisa Voigtländer-BuschmannDepartment of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Lara WaldschmidtDepartment of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Johannes SchirmerDepartment of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Simon PechaDepartment of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Evaldas GirdauskasDepartment of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Stefan BlankenbergDZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.
Hermann ReichenspurnerDepartment of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Niklas SchoferDepartment of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Andreas SchaeferDepartment of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Aortic valve-in-valve procedures for treatment of degenerated surgical bioprostheses are an established therapy. In this study, we evaluated how the risk profiles, procedural approaches, and early outcomes for patients in these procedures changed over a period of 10 years. Methods: Baseline, procedural, early outcome, and echocardiographic parameters were retrospectively compared between three time periods (period 1: 2013-2016, period 2: 2017-2020, and period 3: 2021-2023). Results: Between 2013 and 2023, a total of 256 patients underwent valve-in-valve implantation in degenerated aortic bioprostheses at our center with a steady increase of patient numbers. The median age of the patients was 78.0 (interquartile range 72.2-82.4) years and remained unchanged over time. EuroSCORE II presented lower risk profiles in later periods ( Conclusion: Advancements in technical approaches have expanded eligibility for patients previously considered unsuitable for aortic valve-in-valve procedures. In this study, it was found that early outcomes for patients were excellent, with improvement over time, highlighting the clinical efficacy and safety of the procedures.

Indexed as

aortic valvebioprosthesislifetime managementTAVITAVRvalve-in-valve

Identifiers

PMID41293620
PMCPMC12640918

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