SynthesisFrontiers in cardiovascular medicine2025
Correlation analysis of systemic immune inflammation index with the occurrence and clinical outcomes of hypertension: a systematic review and meta-analysis.
Synthesis in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Evaluation of the Relationship Between the Pan-Immune-Inflammation Score and the Systemic Immune-Inflammation Index and Hypertension: A Retrospective Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Systemic immune-inflammation index combined with blood urea nitrogen to albumin ratio predicts 28-day mortality in sepsis: a retrospective cohort study.Frontiers in physiology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This systematic review and meta-analysis aimed to examine the link between the systemic immune inflammation index (SII) and the incidence and clinical outcomes of hypertension (HTN). Methods: Studies on the link association SII levels with the incidence and prognosis of HTN were retrieved in PubMed, Embase, Web of Science, and Cochrane Library databases. The standardized mean difference (SMD) was employed to discuss the stability of the results and potential sources of heterogeneity. The meta-analysis was performed with Review Manager 5.4.1 and STATA 15.0 software. Results: In total, 19 articles were included, covering 187,195 patients. The results demonstrated that elevated SII was associated with the incidence of HTN (continuous variable: SMD = 1.22, 95% confidence interval [CI]: 0.56, 1.89, Conclusion: SII is potentially associated with the risk and prognosis of HTN, and is likely to become a valuable inflammatory marker for preventing HTN. In light of the inherent limitations of this study, more prospective, large-scale studies are necessary to confirm the findings of this study. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/, PROSPERO CRD42024618091.
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