Evidence map›Paper›PMID 41293543›Full record

ArticleEnvironmental epidemiology (Philadelphia, Pa.)2025

Combined and synergistic effects of heat and fine particulate matter on hospitalization among patients with Alzheimer's disease and related dementias.

Federica Spoto, Antonella Zanobetti, Scott W Delaney, Thomas M Gill, Michelle L Bell, Francesca Dominici, Danielle Braun, Daniel Mork

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental epidemiology (Philadelphia, Pa.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Federica SpotoDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.ORCID https://orcid.org/0009-0005-8953-2330
Antonella ZanobettiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Scott W DelaneyDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Thomas M GillDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Michelle L BellSchool of the Environment, Yale University, New Haven, Connecticut.
Francesca DominiciDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Danielle BraunDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Daniel MorkDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9M
National Cohort Studies of Alzheimer's Disease, Related Dementias and Air PollutionR01AG066793 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ZANOBETTI, ANTONELLA · 2020 to 2025
$4.2M
Susceptibility and adverse health outcomes related to weather-sensitive events among older Medicare beneficiaries with Alzheimer and DementiaR01AG080948 · NIA · YALE UNIVERSITY · PI Michelle L Bell, Tarik Benmarhnia · 2026 to 2026
$725k
NIA NIH HHS P30 AG021342NIA NIH HHS R01 AG066793NIA NIH HHS R01 AG080948NIEHS NIH HHS P30 ES000002
6 · The paper itself

Abstract

Background: Patients with Alzheimer's disease and related dementias (ADRD) are vulnerable to environmental stressors such as extreme heat and air pollution, yet their combined health effects remain poorly understood. Methods: We assessed the joint impact of extreme heat and fine particulate matter exposure (PM Results: We found a linear association between heat and hospitalization, with an odds ratio (OR) of 1.017 (95% confidence interval [CI] = 1.004, 1.031) on extreme heat days (99th percentile) versus median. The PM Conclusion: These findings underscore the need to consider both environmental stressors when assessing health risks in ADRD populations.

Indexed as

Air pollutionAlzheimer’s disease and related dementiasParticulate matterRisk assessmentShort-term exposureTemperature

Identifiers

PMID41293543
PMCPMC12643645

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.