ArticleJournal of Indian Association of Pediatric Surgeons
Urinary Carbohydrate Antigen 19-9 in Children with Unilateral Ureteropelvic Junction Obstruction: Does Bladder Urine Reflect Changes in Renal Pelvis?
Article in Journal of Indian Association of Pediatric Surgeons. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: Urinary carbohydrate antigen 19-9 (CA 19-9) has emerged as a promising noninvasive biomarker in the diagnosis of ureteropelvic junction obstruction (UPJO) in children. However, whether bladder urine reliably reflects biomarker concentrations in the renal pelvis remains uncertain. The aims are to evaluate the diagnostic utility of urinary CA 19-9 levels in children with UPJO and determine if bladder urine levels reflect those from the renal pelvis. Methodology: This prospective case-control study included 72 children from July 2023 to June 2024. The control group ( Results: There was no significant difference in age/sex distribution between the groups. Median CA 19-9 levels (U/mL) were significantly higher in the UPJO group (pelvic: 274.14; bladder: 281.22) compared to controls (3.78, Conclusions: CA 19-9 levels in bladder urine are significantly elevated in children with UPJO and closely correlate with renal pelvic levels. These findings support the use of bladder sampling as a noninvasive test in diagnosing and monitoring UPJO, potentially simplifying clinical evaluation.
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