Evidence map›Paper›PMID 41293479›Full record

Observational studyClinical interventions in aging2025

eGFR-ACR Risk Stratification of Rapid Kidney Function Decline Across Aging Phenotypes in Older Chinese Adults.

Huaiwen Chang, Huaizhou You, Ye Yao, Yan Zheng, JianPing Mao, Yin Yao, Mengjing Wang, Xiaofeng Wang, Jing Chen

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical interventions in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huaiwen ChangDepartment of Computational Biology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.ORCID 0000-0002-8283-7925
Huaizhou YouDivision of Nephrology, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Ye YaoDepartment of Biostatistics, School of Public Health, Fudan University, Shanghai, People's Republic of China.
Yan ZhengNational Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
JianPing MaoDivision of Nephrology, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Yin YaoDepartment of Computational Biology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Mengjing WangDivision of Nephrology, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Xiaofeng WangNational Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Jing ChenDivision of Nephrology, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To develop an estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (ACR) risk stratification for rapid kidney function decline across aging phenotypes in older adults. Methods: We included 1539 older adults (486 healthy aging, 661 aging with comorbidities, 392 aging with CKD) from the Rugao Longevity and Aging Study and Huashan Hospital. Rapid decline was defined as a ≥30% decrease in eGFR over 2 years. We estimated adjusted incidence of rapid decline across baseline eGFR (≥90, 75-<90, 60-<75, <60 mL/min/1.73 m Results: Mean ages were 77.7 ± 4.4, 78.0 ± 4.1, and 77.7 ± 5.5 years in healthy, comorbidity, and CKD cohort, respectively. Among healthy participants, the adjusted incidence remained in low risk when eGFR was between 60 and 75 mL/min/1.73 m Conclusion: Phenotype-specific eGFR-ACR thresholds provide pragmatic risk stratification to guide targeted monitoring and earlier intervention in older adults.

Indexed as

AgingAlbuminuriaCreatinineGlomerular Filtration RateRenal Insufficiency, ChronicAgedAged, 80 and overChinaComorbidityFemaleHumansIncidenceMalePhenotypeRisk AssessmentCreatininechronic kidney diseasecomorbidityglomerular filtration ratehealthy agingkidney function declineurine albumin–creatinine ratio

Identifiers

PMID41293479
PMCPMC12642800

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.