ArticlePeerJ2025
Positive rates of total and specific immunoglobulin E in 7,824 adult patients with suspected allergic diseases in Liaoning Province, China: a retrospective study.
Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The escalating prevalence of allergic diseases poses a significant global health challenge. However, estimates of allergic disease prevalence in Liaoning Province, China, remain lacking. This study aimed to investigate total immunoglobulin E (tIgE) and specific immunoglobulin E (sIgE) levels in 7,824 patients with suspected allergic diseases and to identify factors associated with allergic conditions. Methods: A total of 7,824 participants (3,180 males and 4,644 females) with a mean age of 53.63 years were included. tIgE and sIgE levels were measured using standard laboratory methods. The normal reference range for tIgE was stratified by age group, and sIgE results were categorized as positive or negative based on predefined thresholds. Statistical analysis was performed using SPSS 26.0. Results: The overall tIgE positivity rate was 39.26%, with males showing a significantly higher rate (46.67%) than females (34.19%) ( Conclusions: Male sex, younger and older age groups, and the summer season were identified as significant predictors of allergic diseases based on tIgE levels. These findings underscore the importance of sex and seasonal variations in allergic disease prevalence and highlight the need for targeted prevention and management strategies.
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