Evidence map›Paper›PMID 41293415›Full record

ArticleFrontiers in neurology2025

Accuracy of computed tomography perfusion-defined ischemic core and follow-up infarction after basilar artery thrombectomy.

Pengjun Chen, Xia Li, Yechao Huang, Junguo Hui, Jie Rao, Wenya Zhang, Lijun Shang, Xiao Chen, Ruijie Gao, Jinwei Zhou and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Pengjun ChenZhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, China.
Xia Li *Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, China.
Yechao Huang *Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, China.
Junguo HuiThe Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Jie RaoDepartment of Neurology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, China.
Wenya ZhangZhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, China.
Lijun ShangDepartment of Radiology, Jinyun County People's Hospital, Lishui, China.
Xiao ChenZhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, China.
Ruijie GaoZhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, China.
Jinwei ZhouZhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, China.
Shuiwei XiaZhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, China.
Qiaoling DingDepartment of Radiology, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jiansong JiZhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Accurate identification of computed tomography (CT) perfusion ischemic core in patients with basilar artery occlusion (BAO) on admission remains challenging despite its critical role in prognostic prediction and treatment decision-making. We aimed to define the optimal threshold for identifying the ischemic core by assessing agreement in lesion extent and spatial distribution using Syngo.via. Methods: We retrospectively analyzed 91 patients with BAO who achieved successful recanalization after endovascular thrombectomy at our center. The ischemic core was estimated using the following thresholds: cerebral blood flow (CBF) < 10 or 15 mL/100 g/min by Syngo.via, cerebral blood volume < 1.2 mL/100 mL by Syngo.via, and time to maximum > 10 s by RAPID. The Posterior Circulation Alberta Stroke Program Early CT Score was used to assess the extent of the infarction. Statistical analyses included the intraclass correlation coefficient (ICC) and receiver operating characteristic analyses. Results: The CBF < 10 mL/100 g/min threshold demonstrated good agreement in extent with follow-up infarction (ICC: 0.81 [95% confidence intervals 0.72-0.87]), with overestimation or underestimation being the most uncommon ( Conclusion: In patients with BAO after successful recanalization, the optimal threshold for the ischemic core was a CBF < 10 mL/100 g/min. This threshold may serve as a reliable imaging biomarker, aiding in the prediction of tissue outcomes and treatment decision-making.

Indexed as

basilar arterycomputed tomography perfusionischemic corestrokethrombectomy

Identifiers

PMID41293415
PMCPMC12641287

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