ArticleCureus2025
Saddle Pulmonary Embolism Secondary to Nitrous Oxide Use: A Case Report and Literature Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saddle pulmonary embolism (SPE) is a rare but life-threatening presentation of venous thromboembolism (VTE). Recreational nitrous oxide (N₂O) use has become increasingly common and can cause a functional vitamin B12 deficiency that leads to elevated homocysteine levels and a prothrombotic state. We describe a 31-year-old man with ongoing N₂O abuse who presented with dyspnea and calf pain and was found to have a saddle pulmonary embolus and right leg deep vein thrombosis. Laboratory studies showed low vitamin B12 and high homocysteine levels. He was treated with anticoagulation and discharged in stable condition. This case highlights the need to consider N₂O exposure in patients with unexplained thrombosis, particularly in younger adults.
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