ArticleCureus2025
Bronchoscopic Diagnosis of Pulmonary Sarcoidosis Using Endobronchial Ultrasonography-Guided Transbronchial Needle Aspiration (EBUS-TBNA) and Transbronchial Lung Cryobiopsy (TBLC): A Safe and High-Yield Dual Approach.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA) and transbronchial lung cryobiopsy (TBLC) are widely used to diagnose pulmonary sarcoidosis. However, their combined diagnostic performances and safety profiles have not been comprehensively assessed.
methodsWe retrospectively analyzed 49 consecutive patients who underwent diagnostic bronchoscopy for suspected pulmonary sarcoidosis at a single center between June 2016 and December 2023. Patients were classified into five procedural groups based on the bronchoscopic modality used. The primary outcome was the diagnostic yield, and the secondary outcomes included adverse events and total procedure time.
resultsHistological confirmation was achieved in 87.8% of cases (43/49). The diagnostic yields were 93% for EBUS-TBNA alone, 71% for TBLC alone, and 100% when both were combined. This combination significantly outperformed each technique alone (p=0.003). TBLC did not significantly increase the procedure time or complications. Minor bleeding (grade 1) occurred in 12% of TBLC cases and was effectively managed. The diagnostic yield was positively associated with the number of biopsy samples and specific computed tomography (CT) patterns.
conclusionsThe combination of EBUS-TBNA and TBLC is a safe and highly effective diagnostic approach for pulmonary sarcoidosis, particularly in patients with nodular CT findings. This dual strategy may reduce the need for surgical biopsy and facilitate earlier diagnosis and treatment initiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.