ArticleCureus2025
A Retrospective Study on Temporal Trends in Mortality Related to Atrial Fibrillation and Chronic Obstructive Pulmonary Disease.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Mortality trends and disparities in older U.S. adults with atrial fibrillation and COPD: a 1999-2020 CDC WONDER analysis with forecast to 2030.Frontiers in cardiovascular medicine · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAtrial fibrillation (AF) is a major cause of mortality, and its association with chronic obstructive pulmonary disease (COPD) remains unexplored. Individuals with these diseases have increased mortality and morbidity rates.
aimsThis study aimed to analyze mortality trends and demographic disparities in AF with COPD as a contributing cause using the CDC Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) Multiple Causes of Death (MCD) database from 1999 to 2020. METHODOLOGY: A retrospective observational study was conducted using the CDC WONDER MCD database to assess mortality trends in individuals aged 25 years and older in the United States from 1999 to 2020. The study included deaths where AF (International Classification of Diseases, 10th Revision (ICD-10): I-48) was listed as the underlying cause and COPD (ICD-10: J40-J44) as a contributing cause. Data were analyzed by urbanization, gender, race, geographic region, and place of death. Age-adjusted mortality rates (AAMR) and annual percentage change (APC) were calculated using statistical analysis software JoinPoint, version 5.4.0, developed by the National Cancer Institute, Bethesda, MD.
resultsA total of 37,738 deaths were recorded. The AAMR for AF with COPD increased over time from 1999-2004 (APC: 6.82) to 2004-2015 (APC: 8.37), and then it plateaued from 2015 to 2022 (APC: -0.15). The highest mortality was observed in females, White patients, and metropolitan areas. Temporal trends showed that the mortality increased with time and became steady after 2015; there is a wide disparity in the mortality in races, and more in people living in metropolitan areas.
conclusionsThis study highlights significant mortality trends increasing in all AF with COPD, and from 2015, it is at a steady rate, with disparities by gender, race, and location. Findings underscore the need for targeted prevention strategies and improved healthcare access.
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