ReviewFrontiers in oncology2025
Circulating DNA tumor fraction as a biomarker for advanced breast cancer.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Role of Androgen Receptor and Antiandrogen Therapy in Breast Cancer: A Scoping Review.Current oncology (Toronto, Ont.) · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liquid biopsy has emerged as an important clinical tool for managing a range of tumor types, including advanced breast cancers. Early work in metastatic breast cancer (MBC) demonstrated that circulating tumor DNA (ctDNA) could be reliably detected in patient peripheral blood samples. These discoveries laid the groundwork for more recent work monitoring the circulating DNA tumor fraction, which is the fraction of ctDNA among total cell-free DNA. Studies have shown tumor fraction to be a useful prognostic biomarker in advanced breast cancer. Clinical trials have also begun to explore tumor fraction's role in predicting response to specific therapeutic agents in MBC. Future investigation will be critical to understand when and how tumor fraction should inform clinical decision-making for breast cancer patients in a variety of settings, especially given the increasing accessibility of both commercial and research-based assays that report tumor fraction.
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Registered trials
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