ArticleFrontiers in oncology2025
BTBD19 promotes colorectal cancer progression and correlates with adverse clinical outcomes.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Development and validation of an 11-CpG methylation signature-based nomogram for predicting prognosis in early-onset breast cancer.Translational cancer research · 2026Article
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3 authors.
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Abstract
Background: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. The identification of novel prognostic biomarkers and therapeutic targets is crucial for improving clinical management and patient outcomes. Members of the BTBD (BTB/POZ domain-containing) protein family have been implicated in tumorigenesis, but the role of BTBD19 in CRC remains poorly understood. Objective: This study aimed to investigate the expression pattern of BTBD19 in CRC, its association with clinicopathological features and prognosis, and its potential molecular mechanisms involving functional pathways and immune infiltration. Methods: BTBD19 expression was analyzed using public datasets (TCGA, GEO) and clinical tissue microarrays. Immunohistochemistry (IHC) was performed to validate protein expression. Survival analysis (OS, DSS, PFI) was conducted to assess prognostic significance. Functional enrichment analyses (GO/KEGG/GSEA) and immune infiltration analyses (ESTIMATE, ssGSEA, CIBERSORT) were used to explore underlying molecular mechanisms and immune-related associations. Results: BTBD19 was significantly upregulated in CRC tissues at both mRNA and protein levels compared to normal tissues. High BTBD19 expression was associated with advanced pathologic stages and poor prognosis (OS, DSS, PFI; all p<0.05). Functional analyses revealed that BTBD19-associated genes were enriched in pathways related to extracellular matrix organization, focal adhesion, and epithelial-mesenchymal transition. Immune infiltration analysis showed positive correlations between BTBD19 expression and stromal/immune scores, M2 macrophage infiltration, and expression of immune checkpoints (CD274, PDCD1). Conclusion: BTBD19 is upregulated in CRC and promotes tumor progression. It may serve as a potential prognostic biomarker for CRC, with implications for understanding CRC pathogenesis and immune microenvironment regulation.
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