ArticleFrontiers in pharmacology2025
Effects of Bairui granules (
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Background: The common cold is a prevalent infectious disease affecting the upper respiratory tract worldwide. Wind-heat syndrome is the most common syndrome pattern in traditional Chinese medicine (TCM) associated with the common cold. In this study, we aimed to evaluate the effectiveness and safety of Bairui granules ( Methods: This multicenter, randomized, double-blind, double-dummy, controlled trial, enrolled adults aged 18-65 years were diagnosed with the common cold (wind-heat syndrome). Patients were randomly assigned in a 2:1 ratio, to receive oral Bairui plus Reyanning granule placebo or Reyanning plus Bairui granule placebo. The primary effectiveness endpoint was the disappearance rate of common cold symptoms after 3 days of treatment. The secondary effectiveness endpoint included the rate of symptom relief over time post-treatment and improvement in TCM syndrome scores on the third day. Safety was also assessed in this study. The trial was registered in the Chinese Clinical Trial Registry (ChiCTR2200063903). Results: The main trial population comprised 108 patients in the Bairui group (Bairui + Reyanning granules placebo), and 54 patients in the control group (Reyanning + Bairui granules placebo). Overall, a total of 161 patients completed the trial. The complete symptom resolution rate at day 3 was 41.67% in the Bairui group and 30.19% in the control group ( Conclusion: Bairui Granules significantly improved the resolution rates of fever and sore throat over time compared to Reyanning Granules in patients with the common cold (wind-heat syndrome).
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