ArticleFrontiers in pharmacology2025
The correlation between the use of ondansetron and mortality in sepsis associated encephalopathy patients: a retrospective ICU cohort study.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sepsis-associated encephalopathy (SAE) is a severe complication with high mortality. The effect of ondansetron (OND) on the outcomes of SAE patients remains unclear. Methods: Using the Intensive Care IV Medical Information Mart (MIMIC-IV) database, we identified 7,829 SAE patients, comprising an OND group (n = 3,954) and a non-OND group (n = 3,875). Propensity score matching (PSM) was employed to generate 3,066 pairs of matches in a 1:1 ratio. The primary outcomes encompassed the 30-day, 90-day, 180-day, and 360-day mortality rates. The secondary outcomes included the duration of ICU stay, the duration of mechanical ventilation, and the incidence of QT interval prolongation. Survival analysis was conducted using Cox proportional hazards regression and Kaplan-Meier curves. Sensitivity analyses, including E-value assessment and a landmark analysis at 5 days to address immortal time bias, were performed. Subgroup analysis was applied to investigate potential differences in the effect of OND treatment on clinical outcomes among various subgroups. Result: Following PSM, the baseline characteristics were well-balanced between the cohorts. The group receiving OND demonstrated significantly lower mortality rates at 30 days (HR = 0.64, 95% CI [0.56-0.73], *p*<0.001), 90 days (HR = 0.75, 95% CI [0.66-0.84], *p*<0.001), 180 days (HR = 0.78, 95% CI [0.69-0.88], *p*<0.001), and 360 days (HR = 0.76, 95% CI [0.67-0.85], *p*<0.001) compared with the non-OND group. The landmark sensitivity analysis confirmed the robustness of this survival benefit (p < 0.001). Kaplan-Meier analysis confirmed a significant survival advantage for OND-treated patients with SAE. After matching, the OND group was associated with significantly shorter durations of ICU stay and mechanical ventilation compared with the non-OND group; however, the incidence of QT interval prolongation did not differ significantly between the two groups. Subgroup analysis indicated that adult patients younger than 65 years may derive greater survival benefit from OND treatment. Conclusion: In SAE patients, OND use is associated with significantly lower short- and long-term mortality, suggesting its potential as an adjunct therapy. However, further prospective randomized controlled trials are warranted to validate these results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.