Evidence map›Paper›PMID 41293178›Full record

ArticleFrontiers in immunology2025

Identification of

Santosh A Misal, Jonathan P Renn, Robert D Morrison, Matthew V Cowles, Almahamoudou Mahamar, Oumar Attaher, Alassane Dicko, Patrick E Duffy, Michal Fried

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Santosh A MisalMolecular and Pathogenesis Biomarkers Section, Laboratory of Malaria Immunology and Vaccinology (LMIV), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States.
Jonathan P RennVaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology (LMIV), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States.
Robert D MorrisonVaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology (LMIV), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States.
Matthew V CowlesVaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology (LMIV), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States.
Almahamoudou MahamarMalaria Research & Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Sciences Techniques and Technologies of Bamako, Bamako, Mali.
Oumar AttaherMalaria Research & Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Sciences Techniques and Technologies of Bamako, Bamako, Mali.
Alassane DickoMalaria Research & Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Sciences Techniques and Technologies of Bamako, Bamako, Mali.
Patrick E DuffyVaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology (LMIV), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States.
Michal FriedMolecular and Pathogenesis Biomarkers Section, Laboratory of Malaria Immunology and Vaccinology (LMIV), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Placental malaria is associated with adverse outcomes for both mothers and their newborn children. During pregnancy, Methods: To identify and quantify epitopes differentially recognized by IgG of multigravidae that acquired anti-adhesion antibodies compared to primigravidae that did not, we applied epitope excision and multiplex isobaric labeling to quantify epitope recognition by naturally acquired antibodies. Results: While primigravidae and multigravidae IgG reacted similarly to most epitopes, multigravidae IgG differentially recognized (Log2 fold change > 1, p < 0.05) ten epitopes conserved across multiple VAR2CSA alleles. Conclusion: Knowledge of VAR2CSA epitopes preferentially recognized by immune multigravidae will be valuable for designing a VAR2CSA subunit vaccine.

Indexed as

Antibodies, ProtozoanAntigens, ProtozoanEpitopesImmunoglobulin GMalaria, FalciparumPeptidesPlasmodium falciparumPregnancy Complications, ParasiticAdultErythrocytesFemaleHumansMalaria VaccinesPregnancyAntibodies, ProtozoanAntigens, ProtozoanEpitopesImmunoglobulin GMalaria VaccinesPeptidesVAR2CSA protein, Plasmodium falciparumepitope excisionepitope mappingmalariaPlasmodium falciparumpregnancy malaria vaccineVAR2CSA vaccine

Identifiers

PMID41293178
PMCPMC12641020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.