ReviewJournal of pain research2025
Comparative Effectiveness of Pharmacological, Non-Pharmacological, and Combined Strategies for Pain Relief During Colonoscopy: A Bayesian Network Meta-Analysis of Randomized Trials.
Review in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Colonoscopy is the gold standard for colorectal cancer screening, but procedural pain remains a major barrier to patient compliance. Various pharmacological and non-pharmacological interventions have been developed to improve patient comfort, yet the comparative effectiveness of these strategies remains unclear. Methods: We systematically searched five databases for randomized controlled trials published between 2004 and 2024 that evaluated analgesic interventions for colonoscopy and performed a Bayesian random-effects network meta-analysis. We analyzed two pre-specified subnetworks-non-pharmacological and pharmacological/combined-according to intervention type. The primary outcome was pain on a visual analogue scale. Results: 40 RCTs (5614 participants, 32 interventions) were included. Compared to blank control: 1) Combined physical intervention + analgesia/sedation (MD = -2.7, 95% CrI: -5.3 to -0.15) and water perfusion/CO Conclusion: Multimodal strategies that combine pharmacological agents, especially pethidine or propofol, with non-pharmacological techniques such as CO
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