Evidence map›Paper›PMID 41293014›Full record

ArticlebioRxiv : the preprint server for biology2025

Impact of early locus coeruleus lesions in the TgF344 Alzheimer's disease rat model.

Alexia E Marriott, Jason P Schroeder, Anu Korukonda, Brittany S Pate, Katharine E McCann, David Weinshenker, Michael A Kelberman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Alexia E MarriottDepartment of Human Genetics, Emory University, Atlanta, GA 30322.
Jason P SchroederDepartment of Human Genetics, Emory University, Atlanta, GA 30322.
Anu KorukondaDepartment of Human Genetics, Emory University, Atlanta, GA 30322.
Brittany S PateDepartment of Human Genetics, Emory University, Atlanta, GA 30322.
Katharine E McCannDepartment of Human Genetics, Emory University, Atlanta, GA 30322.
David WeinshenkerDepartment of Human Genetics, Emory University, Atlanta, GA 30322.
Michael A KelbermanDepartment of Human Genetics, Emory University, Atlanta, GA 30322.

Funding

The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI Amy D Rodriguez · 2020 to 2026
$29.0M
Training In Systems And Integrative Biology NeuroscienceT32NS096050 · NINDS · EMORY UNIVERSITY · PI Yoland Smith · 2016 to 2026
$3.9M
Impact of locus coeruleus-derived tau pathology in a rodent model of early Alzheimer's diseaseR01AG062581 · NIA · EMORY UNIVERSITY · PI KEILHOLZ, SHELLA D, WEINSHENKER, DAVID · 2020 to 2024
$2.3M
Local and global consequences of hyperphosphorylated tau in the locus coeruleus in Alzheimer's DiseaseF31AG069502 · NIA · EMORY UNIVERSITY · PI KELBERMAN, MICHAEL · 2020 to 2022
$138k
NIA NIH HHS F31 AG069502NIA NIH HHS P30 AG066511NIA NIH HHS R01 AG062581NINDS NIH HHS T32 NS096050
6 · The paper itself

Abstract

introductionIn murine models of Alzheimer's disease (AD), lesioning the locus coeruleus-norepinephrine (LC-NE) system with DSP-4 exacerbates AD-like neuropathology and cognitive impairment. However, the impact of LC lesions during prodromal stages is poorly characterized.

methodsTgF344-AD and wild-type rats received monthly injections of DSP-4 or saline from 1-5 months of age, a time point preceding forebrain plaque or tangle deposition in TgF344-AD rats, after which behavior and pathology were assessed.

resultsDSP-4 compromised LC cell bodies, fibers, and NE content. LC lesion and the AD transgene each affected several affective behaviors and/or cognition individually, but few interactions were found and DSP-4 failed to exacerbate behavioral phenotypes or neuropathology in TgF344-AD rats. DISCUSSION: Combined with previous literature, our data suggest that LC lesions exacerbate pre-existing AD-like pathology and behavioral impairments, rather than accelerate their onset. Further characterization of LC lesions in TgF344-AD rats at different ages is warranted.

Indexed as

Alzheimer’s diseaseDSP-4locus coeruleusneurodegenerative diseasesneuropsychiatric symptomsnorepinephrineTgF344-AD

Identifiers

PMID41293014
PMCPMC12642694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.