Evidence map›Paper›PMID 41293003›Full record

ArticlebioRxiv : the preprint server for biology2025

Variable Schwann cell merlin inactivation is targetable with TEAD1 inhibition in schwannomas.

Maxwell T Laws, Dhruval Bhatt, Debjani Mandal, Nikhil Ramavenkat, David T Asuzu, Stefan Stoica, Ihika Rampalli, Dustin Mullaney, Liyam Laraba, Hannah Odom and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Maxwell T LawsNeurosurgery Unit for Pituitary and Inheritable Diseases, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Dhruval BhattNeurosurgery Unit for Pituitary and Inheritable Diseases, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Debjani MandalNeurosurgery Unit for Pituitary and Inheritable Diseases, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Nikhil RamavenkatNeurosurgery Unit for Pituitary and Inheritable Diseases, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
David T AsuzuNeurosurgery Unit for Pituitary and Inheritable Diseases, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Stefan StoicaNeurosurgery Unit for Pituitary and Inheritable Diseases, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Ihika RampalliNeurosurgery Unit for Pituitary and Inheritable Diseases, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Dustin MullaneyNeurosurgery Unit for Pituitary and Inheritable Diseases, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Liyam LarabaPlymouth University School of Medicine and Dentistry, Plymouth, PL4 8AA, United Kingdom.
Hannah OdomSection on Omics and Translational Science of Hearing, National Institute on Deafness and Other Communication Disorders, Bethesda, MD.
Niveditha RavindraNeurosurgery Unit for Pituitary and Inheritable Diseases, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Sheelu VargheseNeurosurgery Unit for Pituitary and Inheritable Diseases, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Tracy TangVivace Therapeutics, Inc. San Mateo, CA.
Xiyuan ZhangDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Rutgers Cancer Institute, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ.
John F ShernTumor Evolution and Genomics Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Abdel ElkahlounCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, Bethesda, MD.
Bayu SisayCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, Bethesda, MD.
Dragan MaricFlow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Kory JohnsonDIR Bioinformatics Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Zied AbdullaevNeurosurgery Unit for Pituitary and Inheritable Diseases, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Kenneth AldapeLaboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Ronna P HertzanoSection on Omics and Translational Science of Hearing, National Institute on Deafness and Other Communication Disorders, Bethesda, MD.
Hung N KimNeurootology Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, MD.
David ParkinsonPlymouth University School of Medicine and Dentistry, Plymouth, PL4 8AA, United Kingdom.
Prashant ChittiboinaNeurosurgery Unit for Pituitary and Inheritable Diseases, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD.ORCID 0000-0001-9349-4756

Funding

Improved Diagnosis and Treatment of Cushing's DiseaseZIANS003150 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI CHITTIBOINA, PRASHANT · 2015 to 2025
$13.7M
Intramural NIH HHS ZIA NS003150
6 · The paper itself

Abstract

Schwann cell tumors occur frequently in association with the vestibular nerves, leading to sensorineural hearing loss, and brainstem compression. In humans, unilateral vestibular schwannomas (VS) occur sporadically (VS

Indexed as

hippo pathwaymerlinmulti-omicsNF2TEADvestibular schwannoma

Identifiers

PMID41293003
PMCPMC12642662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.