Evidence map›Paper›PMID 41292998›Full record

ArticlebioRxiv : the preprint server for biology2025

N6-methyladenosine regulation of mRNA translation is essential for early human erythropoiesis.

Daniel A Kuppers, Sonali Arora, Cindy L Wladyka, Ruiqi Ge, Shun Liu, Yong Peng, Rui Su, Anne Wilhite, Jianjun Chen, Chuan He and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniel A KuppersHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Sonali AroraHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Cindy L WladykaHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Ruiqi GeDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Shun LiuDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Yong PengDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Rui SuDepartment of Systems Biology and Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Anne WilhiteHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Jianjun ChenDepartment of Systems Biology and Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Chuan HeDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Andrew C HsiehHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Patrick J PaddisonHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
CORE--VECTOR PRODUCTIONP30DK056465 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HEIMFELD, SHELLY · 1999 to 2014
$14.9M
Stem Cell and Transplantation BiologyU54DK106829 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DEREK L STIREWALT · 2015 to 2026
$9.1M
Hormone signaling and translation control in advanced prostate cancerR37CA230617 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HSIEH, ANDREW CALEB · 2019 to 2025
$3.1M
TET2-mediated epitranscriptomic regulation in leukemia microenvironmentR01CA280389 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Jianjun Chen · 2023 to 2026
$2.7M
Transcriptional-translational conflict in bladder epithelial homeostasis and cancerR01CA276308 · NCI · FRED HUTCHINSON CANCER CENTER · PI Andrew Caleb Hsieh · 2023 to 2026
$2.3M
Selective mRNA translation in developmental disordersR01GM135362 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BERONJA, SLOBODAN, HSIEH, ANDREW CALEB · 2020 to 2023
$2.1M
Epitranscriptomic control of erythropoiesisR01DK119270 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PADDISON, PATRICK · 2019 to 2022
$1.8M
NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA276308NCI NIH HHS R01 CA280389NCI NIH HHS R37 CA230617NIDDK NIH HHS P30 DK056465NIDDK NIH HHS R01 DK119270NIDDK NIH HHS U54 DK106829NIGMS NIH HHS R01 GM135362
6 · The paper itself

Abstract

N6-methyladenosine (m

Indexed as

Erythropoiesism6AMETTL3mRNA methylationN6-methyladenosinetranslation

Identifiers

PMID41292998
PMCPMC12642496

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.