Evidence map›Paper›PMID 41292994›Full record

ArticlebioRxiv : the preprint server for biology2025

ICAM-5: A Novel Marker for Neuronally Derived Extracellular Vesicles.

Piper Deleon, Reagan Hattenberger, Barbara Knollmann-Ritschel, Manish Bhomia

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Piper DeleonDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD.
Reagan HattenbergerDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD.
Barbara Knollmann-RitschelDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD.
Manish BhomiaDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD.ORCID 0000-0003-2808-9927

Funding

Characterization of neuronal derived exosomes to detect biomarkers for neurodegenerative disordersR21NS116710 · NINDS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI BHOMIA, MANISH · 2020 to 2020
$422k
NINDS NIH HHS R21 NS116710
6 · The paper itself

Abstract

Current methods for isolating neuronal-derived extracellular vesicles (NDEVs) from human biofluids lack specificity. In addition, some of the reported markers for NDEV isolation are present as soluble proteins instead of extracellular vesicle (EV) associated proteins. To address the research gap, this study aimed to identify a novel marker for NDEV isolation that is NDEV associate and highly specific to the central nervous system. To achieve this, human cortical neurons were used for isolation of EVs

Indexed as

BiofluidsBiomarkerExtracellular vesicles

Identifiers

PMID41292994
PMCPMC12642397

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.