Evidence map›Paper›PMID 41292962›Full record

ArticlebioRxiv : the preprint server for biology2025

Spinal cord regeneration deploys cell-type specific developmental and non-developmental strategies to restore neuron diversity.

Avery Angell Swearer, Samuel B Perkowski, Iba Husain, Thiago A Figueiredo, Morgan E McCartney, Andrea E Wills

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Avery Angell SwearerProgram in Molecular and Cell Biology, University of Washington, Seattle, WA.
Samuel B PerkowskiDepartment of Biochemistry, University of Washington School of Medicine, Seattle, WA.
Iba HusainDepartment of Biochemistry, University of Washington School of Medicine, Seattle, WA.
Thiago A FigueiredoDepartment of Biochemistry, University of Washington School of Medicine, Seattle, WA.
Morgan E McCartneyDepartment of Biochemistry, University of Washington School of Medicine, Seattle, WA.
Andrea E WillsProgram in Molecular and Cell Biology, University of Washington, Seattle, WA.ORCID 0000-0003-3647-8105

Funding

Training in Cellular & Molecular BiologyT32GM136534 · NIGMS · UNIVERSITY OF WASHINGTON · PI Andrew Atwell Oberst, LARRY S ZWEIFEL · 2021 to 2026
$5.8M
Transcriptional regulatory mechanisms of vertebrate regenerationR01NS099124 · NINDS · UNIVERSITY OF WASHINGTON · PI Andrea Elizabeth Wills · 2017 to 2026
$3.3M
NIGMS NIH HHS T32 GM136534NINDS NIH HHS R01 NS099124
6 · The paper itself

Abstract

A major goal of spinal cord injury research is to develop a path to endogenous regeneration. This approach has been heavily informed by animal models of natural regeneration. An unresolved question is whether these models rebuild the spinal cord by exclusively accessing developmental mechanisms of neuron differentiation. To address this question, we contrasted single-cell gene expression during regeneration with stage-matched controls in the conditionally regenerative frog

Indexed as

neural progenitor cellneurogenesisneuronregenerationSpinal cordXenopus

Identifiers

PMID41292962
PMCPMC12642675

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.