Evidence map›Paper›PMID 41292956›Full record

ArticlebioRxiv : the preprint server for biology2025

Proteolytic activation of diverse antiviral defense modules in prokaryotes.

Simone A Evans, Jianxiu Zhang, Yannie Lam, Katherine Wang, Yu Tin Lin, Daniel Herschlag, Liang Feng, Alex Gao

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Simone A EvansDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-4975-8747
Jianxiu ZhangDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-1864-7510
Yannie LamDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0009-0003-9472-2679
Katherine WangDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0009-0004-9596-3244
Yu Tin LinDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0009-0003-9517-9225
Daniel HerschlagDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-4685-1973
Liang FengDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA.
Alex GaoDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-3579-0327

Funding

Genetics and Developmental Biology Training ProgramT32GM141828 · NIGMS · STANFORD UNIVERSITY · PI MARGARET T FULLER, Gavin J Sherlock · 2022 to 2026
$2.6M
Molecular mechanisms of mitochondrial membrane transport systems in cellular energeticsR35GM153424 · NIGMS · STANFORD UNIVERSITY · PI Liang Feng · 2024 to 2026
$2.5M
NIGMS NIH HHS R35 GM153424NIGMS NIH HHS T32 GM141828
6 · The paper itself

Abstract

Linked protease-effector modules are widespread in prokaryotic antiviral defense, yet the mechanisms of most remain poorly understood. Here we show that four of the most prevalent modules-metallo-β-lactamase (MBL)-fold hydrolase, α/β-hydrolase, Pepco, and EACC1-form latent death effectors that are unleashed by site-specific proteolysis. Genetic, biochemical, and structural analyses reveal novel modes of effector licensing. MBL and α/β-hydrolase are zymogens activated by cleavage at two distinct sites, and upon proteolysis, MBL becomes a Zn

Identifiers

PMID41292956
PMCPMC12642450

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.