Evidence map›Paper›PMID 41292952›Full record

ArticlebioRxiv : the preprint server for biology2025

An infusible decellularized extracellular matrix material binds to vasculature in infarcted myocardium and induces pro-reparative gene expression following acute myocardial infarction through inherent avidity and bioactive signaling.

Michael B Nguyen, Alexander Chen, Van K Ninh, Maxwell C McCabe, Quincy Lyons, Colin Luo, Benjamin D Bridgelal, Connor Uhre, Julian Cheng, Kate E Reimold and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michael B NguyenShu Chien-Gene Lay Department of Bioengineering, University of California San Diego.ORCID 0000-0003-1847-4557
Alexander ChenSanford Consortium for Regenerative Medicine, University of California San Diego.
Van K NinhDepartment of Medicine, Division of Cardiology, University of California San Diego.
Maxwell C McCabeDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado, Aurora, Colorado 80045, USA.
Quincy LyonsShu Chien-Gene Lay Department of Bioengineering, University of California San Diego.
Colin LuoShu Chien-Gene Lay Department of Bioengineering, University of California San Diego.
Benjamin D BridgelalShu Chien-Gene Lay Department of Bioengineering, University of California San Diego.
Connor UhreShu Chien-Gene Lay Department of Bioengineering, University of California San Diego.
Julian ChengShu Chien-Gene Lay Department of Bioengineering, University of California San Diego.
Kate E ReimoldShu Chien-Gene Lay Department of Bioengineering, University of California San Diego.
Selena CaoShu Chien-Gene Lay Department of Bioengineering, University of California San Diego.
Kirk C HansenDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado, Aurora, Colorado 80045, USA.
Kevin R KingShu Chien-Gene Lay Department of Bioengineering, University of California San Diego.
Karen L ChristmanShu Chien-Gene Lay Department of Bioengineering, University of California San Diego.

Funding

Training in Multi-Scale Analysis of Biological Structure and FunctionT32EB009380 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrew D. McCulloch, Padmini Rangamani · 2009 to 2026
$4.8M
Infusible Extracellular Matrix for Treating Myocardial InfarctionR01HL165232 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTMAN, KAREN L · 2022 to 2025
$2.9M
Training in Bioengineering Research and Technology Development in Cardiovascular in Cardiopulmonary Health and DiseaseT32HL160507 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Karen L Christman, Andrew D. McCulloch · 2022 to 2026
$1.6M
NHLBI NIH HHS R01 HL165232NHLBI NIH HHS T32 HL160507NIBIB NIH HHS T32 EB009380
6 · The paper itself

Abstract

To treat acute myocardial infarction immediately after reperfusion, we previously engineered an intravascularly infusible decellularized extracellular matrix (iECM) biomaterial that exerts immunomodulatory and pro-reparative effects. However, the impact of the heterogeneous contents of iECM on infarct localization and downstream biological function is unknown. Using liquid chromatography, iECM is separated into a high molecular weight (MW) and low MW component. Mass spectrometry confirms compositional similarity, while biochemical assays and transmission electron microscopy highlight differences in biochemical features and structure, revealing a nanofibrillar high MW component and a globular peptide low MW. Quartz crystal microbalance studies show binding of each component to basal lamina ECM proteins and endothelial cell surface receptors under flow, demonstrating the specificity of ECM biomaterials to permeable vasculature.

Identifiers

PMID41292952
PMCPMC12642560

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.