Evidence map›Paper›PMID 41292947›Full record

ArticlebioRxiv : the preprint server for biology2025

A Population-Specific PARP1 Gene Variation Modulates PARP Trapping.

Jin Cai, Ramya Billur, Michael S Cohen, Andreas G Ladurner, Ben E Black

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jin CaiDepartment of Physiological Chemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.
Ramya BillurDepartment of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael S CohenDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA.
Andreas G LadurnerDepartment of Physiological Chemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.
Ben E BlackDepartment of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-3707-9483

Funding

Tuning PARP-1 retention and release on DNA breaksR01CA259037 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Ben E. Black, John M Pascal · 2022 to 2026
$2.9M
NCI NIH HHS R01 CA259037
6 · The paper itself

Abstract

Poly-(ADP-ribose) polymerase inhibitors (PARPi) block NAD

Identifiers

PMID41292947
PMCPMC12642684

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.