Evidence map›Paper›PMID 41292931›Full record

ArticlebioRxiv : the preprint server for biology2025

Delta Opioid Receptors on Parvalbumin Neurons are Necessary for the Convulsant and Anxiolytic Effects of the Delta Agonist SNC80.

Marie C Walicki, Matthew R Mueller, Alejandrina Raigosa Garza, Erica S Levitt, John R Traynor, Emily M Jutkiewicz, William T Birdsong

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Marie C WalickiDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-0345-1010
Matthew R MuellerDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, USA.
Alejandrina Raigosa GarzaDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, USA.
Erica S LevittDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3634-6594
John R TraynorDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-1849-8316
Emily M JutkiewiczDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-1154-1684
William T BirdsongDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-3514-9158

Funding

NIDA Training Program in Neuroscience-Administrative SupplementT32DA007281 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Shelly Beth Flagel · 1995 to 2026
$5.7M
Brainstem mechanisms of opioid-induced respiratory depressionR01HL174547 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Erica Sawyer Levitt · 2024 to 2026
$1.6M
NHLBI NIH HHS R01 HL174547NIDA NIH HHS T32 DA007281
6 · The paper itself

Abstract

The delta opioid receptor (DOR) is expressed broadly throughout the central and peripheral nervous systems. Activation of DOR by exogenous and endogenous ligands regulates pain, motivation, emotion and memory, but the cells and neural circuits mediating these behavioral effects remain poorly characterized. Parvalbumin-expressing (PV) interneurons express high levels of DOR transcript (

Identifiers

PMID41292931
PMCPMC12642499

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.