Evidence map›Paper›PMID 41292921›Full record

ArticlebioRxiv : the preprint server for biology2025

The ESCRT-0 protein HRS regulates hepatocellular lipid droplet catabolism.

Mathilda M Willoughby, Ankit Shroff, Bridget E Crossman, Micah B Schott

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Mathilda M WilloughbyDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, USA.
Ankit ShroffDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, USA.
Bridget E CrossmanDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.
Micah B SchottDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, USA.

Funding

Mechanisms of endosomal trafficking in lipid droplet catabolismR35GM150801 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Micah Schott · 2023 to 2026
$1.8M
Synergy of lipolysis and lipophagy in alcoholic liver diseaseR00AA026877 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SCHOTT, MICAH · 2021 to 2023
$747k
NIAAA NIH HHS R00 AA026877NIGMS NIH HHS R35 GM150801
6 · The paper itself

Abstract

Lipid droplets (LDs) are dynamic organelles that regulate lipid storage and metabolism pathways central to metabolic liver disease. LD turnover occurs in part through lysosomal catabolism (i.e. lipophagy) whereby LDs are thought to follow two distinct trafficking pathways: autophagosome-dependent

Indexed as

AutophagyESCRTLipophagyMacrolipophagyMicrolipophagy

Identifiers

PMID41292921
PMCPMC12642657

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.