Evidence map›Paper›PMID 41292916›Full record

ArticlebioRxiv : the preprint server for biology2025

Lgr5+ Stem Cells Maintain Apex Position in Cell Hierarchy of the Intestinal Epithelium During Homeostasis and Injury.

Julian Chua, Lucy Driver, Masahiro Narimatsu, Mardi Fink, Lixia Luo, Jordan Tran, Arshdeep Kaur, Rida Habib, Jatin Roper, David G Kirsch and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Julian ChuaDepartment of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Lucy DriverDepartment of Pathology, Duke University, Durham, NC, USA.
Masahiro NarimatsuCentre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Mardi FinkRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, ON, Canada.
Lixia LuoDepartment of Radiation Oncology, Duke University, Durham, NC, USA.
Jordan TranDepartment of Radiation Oncology, Duke University, Durham, NC, USA.
Arshdeep KaurDepartment of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Rida HabibDepartment of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Jatin RoperDivision of Gastroenterology, Department of Medicine, Duke University, Durham, NC, USA.
David G KirschRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, ON, Canada.
Jeffrey L WranaCentre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Chang-Lung LeeDepartment of Pathology, Duke University, Durham, NC, USA.
Arshad AyyazDepartment of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.ORCID 0009-0004-8573-2012

Funding

Somatostatin analogues as countermeasures against intestinal radiation toxicityU19AI067798 · NIAID · DUKE UNIVERSITY · PI CHAO, NELSON J. · 2005 to 2024
$82.1M
Wnt signaling in obesity-associated colorectal cancerR37CA259363 · NCI · DUKE UNIVERSITY · PI Jatin Roper · 2022 to 2026
$1.8M
Mitigation of gastrointestinal acute radiation syndrome by promoting clusterin-mediated intestinal regenerationU01AI186969 · NIAID · DUKE UNIVERSITY · PI David Guy Kirsch, Chang-Lung Lee · 2025 to 2026
$1.0M
Epigenetic mechanisms of intestinal stem cell fate conversion in response to severe radiation injuryR21AI193496 · NIAID · DUKE UNIVERSITY · PI Christine Elissa Eyler, Chang-Lung Lee · 2025 to 2026
$317k
NCI NIH HHS R37 CA259363NIAID NIH HHS R21 AI193496NIAID NIH HHS U01 AI186969NIAID NIH HHS U19 AI067798
6 · The paper itself

Abstract

The cellular origin of intestinal epithelial homeostasis and regeneration has been a subject of continued debate, with recent models challenging the primacy of WNT-dependent Lgr5

Indexed as

chromatin accessibilitycrypt base columnar cellsepithelial plasticityfetal-like reprogrammingLgr5+ stem cellsregenerationrevival stem cellssingle-cell transcriptomicsstem cell hierarchyWNT/β-catenin signalling

Identifiers

PMID41292916
PMCPMC12642652

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.