ArticlebioRxiv : the preprint server for biology2025
On Temporal Robustness & Brain-State Stability of Functional Connectivity in Mouse Primary Visual Area V1 compared to Higher Visual Area AL.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Understanding how the structure of functional connectivity in the visual cortex changes over time and across brain states is crucial for elucidating the mechanisms by which neurons coordinate to process information and support behavior. Higher-order visual areas in mice are known to exhibit more distinct, segregated functional roles compared to the primary visual cortex (V1) [1], and they maintain stimulus representations over extended time scales [2]. However, the stability of the architecture of their functional connectivity across time and brain states remains less understood. In vivo mesoscopic two-photon calcium imaging was used to simultaneously record activity from thousands of neurons across V1 and the extra-striate anterolateral area (AL) in mice, during both visual stimulation (optical-flow/motion) and at resting state (i.e., absence of stimulus). We then applied the spike time-tiling (STTC) coefficient [3] to estimate the pairwise correlations of the neuronal firing and form the
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