Evidence map›Paper›PMID 41292888›Full record

ArticlebioRxiv : the preprint server for biology2025

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Karina Lezgiyeva, Jingyi Liu, Karen Nguyen, Michelle M DeLisle, Frank C Ko, Spencer Fullam, Alia M Obeidat, Josef Turecek, Ilayda Alkislar, Brendan P Lehnert and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Karina LezgiyevaDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115.ORCID 0009-0001-3666-9115
Jingyi LiuDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115.
Karen NguyenDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115.
Michelle M DeLisleDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115.
Frank C KoDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA.
Spencer FullamDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA.
Alia M ObeidatDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA.
Josef TurecekDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115.
Ilayda AlkislarDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115.
Brendan P LehnertDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115.
Rosa I Martinez-GarciaDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115.
Riya SivakumarDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115.
Jinheon ChoiDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115.
Ofer MazorDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115.
Lilit GaribyanWellman Center for Photomedicine, Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, 50 Blossom St, Boston, MA 02114.
Nikhil SharmaDepartment of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032.
Alan J EmanuelDepartment of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322.
Anne-Marie MalfaitDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA.
Rachel E MillerDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA.
David D GintyDepartment of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115.

Funding

Viral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MARGARET S LIVINGSTONE · 1998 to 2026
$21.3M
Precision Mapping of Knee Pain in Osteoarthritis: Understanding differences between pain with activity and restUC2AR082186 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI LOTZ, MARTIN K, MALFAIT, ANNE-MARIE · 2022 to 2025
$11.9M
Osteoarthritis Progression And Sensory Pathway AlterationsR01AR064251 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI MALFAIT, ANNE-MARIE, MILLER, RICHARD J · 2013 to 2025
$7.6M
Elucidating Cutaneous Mechanosensory Circuits, from Development to DiseaseR35NS097344 · NINDS · HARVARD MEDICAL SCHOOL · PI GINTY, DAVID D · 2016 to 2023
$6.8M
Molecular Pathways of Pain Generation in OsteoarthritisR01AR060364 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI MALFAIT, ANNE-MARIE · 2011 to 2025
$6.0M
Spinal Cord Nociceptive Circuits that Deliver Outputs to the Brain to Initiate PainR01AT011447 · NCCIH · HARVARD MEDICAL SCHOOL · PI DRUGOWITSCH, JAN, GINTY, DAVID D · 2020 to 2024
$5.3M
Neurobiology Core CP30AR079206 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI Anne-Marie Malfait · 2021 to 2026
$4.7M
The Role of Mechanosensation Pathways in Osteoarthritis Joint Damage and PainR01AR077019 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI Rachel Elizabeth Miller · 2021 to 2026
$2.7M
Elucidating Cutaneous Mechanosensory Circuits, from Development to DiseaseR35NS132196 · NINDS · HARVARD MEDICAL SCHOOL · PI David D GINTY · 2024 to 2026
$1.8M
NCCIH NIH HHS R01 AT011447NEI NIH HHS P30 EY012196NIAMS NIH HHS P30 AR079206NIAMS NIH HHS R01 AR060364NIAMS NIH HHS R01 AR064251NIAMS NIH HHS R01 AR077019NIAMS NIH HHS UC2 AR082186NINDS NIH HHS R35 NS097344NINDS NIH HHS R35 NS132196
6 · The paper itself

Abstract

Nociceptors detect damaging stimuli and evoke pain in healthy animals. We conducted an optogenetic activation screen to identify genetically defined nociceptor populations that elicit place aversion and nocifensive behaviors in response to stimulation.

Identifiers

PMID41292888
PMCPMC12642651

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.