Evidence map›Paper›PMID 41292881›Full record

ArticlebioRxiv : the preprint server for biology2025

Proteome-wide identification of metamorphic protein candidates using mass spectrometry.

Baiyi Ǫuan, Yanping Ǫiu, Kathleen Carillo, Andy LiWang, John Orban, Tsui-Fen Chou

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Baiyi ǪuanProteome Exploration Laboratory, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0001-6313-4274
Yanping ǪiuProteome Exploration Laboratory, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0003-2948-2173
Kathleen CarilloUniversity of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.ORCID 0009-0006-1632-5709
Andy LiWangDepartment of Chemistry and Biochemistry, University of California, Merced, CA 95343.ORCID 0000-0003-4741-6946
John OrbanUniversity of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.ORCID 0000-0002-3895-1800
Tsui-Fen ChouProteome Exploration Laboratory, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0003-2410-2186

Funding

Structure and stability of 3_alpha vs alpha_beta foldsR01GM062154 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI BRYAN, PHILIP N, ORBAN, JOHN · 2002 to 2016
$3.2M
Temperature and metabolic compensation mechanisms in a circadian clock systemR35GM144110 · NIGMS · UNIVERSITY OF CALIFORNIA, MERCED · PI Andy LiWang · 2022 to 2026
$2.2M
NIGMS NIH HHS R01 GM062154NIGMS NIH HHS R35 GM144110
6 · The paper itself

Abstract

How protein folds remodel at low temperature remains poorly mapped at the proteome scale. We combine brief, temperature-controlled proteolysis with LC-MS/MS to chart cold-dependent conformational changes in

Identifiers

PMID41292881
PMCPMC12642558

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.