Evidence map›Paper›PMID 41292879›Full record

ArticlebioRxiv : the preprint server for biology2025

Anti-CD3 microporous annealed particle hydrogel protects stem cell derived beta cells from autoreactive T cells.

Adrienne E Widener, Cameron T Manson, Jessie M Barra, Christopher P Spencer, Amanda D Grodman, Andrew M Ladd, Holger A Russ, Edward A Phelps

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adrienne E WidenerJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.ORCID 0009-0008-7401-3441
Cameron T MansonJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.ORCID 0009-0003-5371-6483
Jessie M BarraDepartment of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-6456-9293
Christopher P SpencerJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.ORCID 0009-0009-3626-1847
Amanda D GrodmanDepartment of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.ORCID 0009-0000-8481-2863
Andrew M LaddDepartment of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.ORCID 0009-0005-8566-1485
Holger A RussJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-5117-2927
Edward A PhelpsJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-8666-805X

Funding

Local immune modulation for beta cell replacement therapy in type 1 diabetesR01DK132387 · NIDDK · UNIVERSITY OF FLORIDA · PI PHELPS, EDWARD, RUSS, HOLGER A. · 2022 to 2025
$2.1M
Mechanism and dynamics of islet GABA signalingR01DK124267 · NIDDK · UNIVERSITY OF FLORIDA · PI PHELPS, EDWARD · 2021 to 2025
$1.8M
NIDDK NIH HHS R01 DK124267NIDDK NIH HHS R01 DK132387
6 · The paper itself

Abstract

Type 1 diabetes (T1D) results from autoimmune destruction of pancreatic beta cells, leaving patients dependent on exogenous insulin and at risk of severe hypoglycemic episodes. Stem cell-derived beta-like cells (sBCs) offer a promising approach for beta cell replacement therapy, but clinical translation is limited by immune-mediated rejection, recurrent autoimmunity, and inhospitable transplantation sites. Biomaterials have been investigated to provide localized immune-isolation and immunomodulation, but foreign body responses and rapid depletion of therapeutic agents remain as obstacles to clinical translation. Here, we present a microporous annealed particle (MAP) hydrogel functionalized with an anti-CD3 monoclonal antibody (αCD3) to provide a localized immunomodulatory microenvironment for beta cell replacement therapy. MAP hydrogels consisting of guest-host interlinked polyethylene glycol-maleimide (PEG-MAL) microgels supported rapid vascularization, minimal foreign body response, and engraftment of syngeneic islets in mice. αCD3 MAP hydrogel halted T cell migration

Indexed as

autoreactive T cellsbeta cell replacementbiomaterialimmune therapyislet transplantationmicroporous annealed particlesstem cell-derived beta cellsType 1 diabetes

Identifiers

PMID41292879
PMCPMC12642621

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.