Evidence map›Paper›PMID 41292873›Full record

ArticlebioRxiv : the preprint server for biology2025

UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors.

Avery J Benton, Mia R Johns, Emil Diamant, Nirvan Rouzbeh, Valdemar P Sørensen, Carly M Anderson, Davide Secci, Zhucheng Zhang, Andrew R Rau, Rasmus P Clausen and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Avery J BentonCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, MT.ORCID 0000-0001-9063-6712
Mia R JohnsCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, MT.ORCID 0009-0006-6631-5453
Emil DiamantCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, MT.
Nirvan RouzbehCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, MT.ORCID 0009-0000-7627-7661
Valdemar P SørensenCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, MT.
Carly M AndersonCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, MT.ORCID 0009-0006-5680-3832
Davide SecciDepartment for Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0009-0005-4468-5018
Zhucheng ZhangDepartment for Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0009-0006-3814-5637
Andrew R RauCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, MT.ORCID 0000-0002-7983-6809
Rasmus P ClausenDepartment for Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-9466-9431
Kasper B HansenCenter for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, MT.ORCID 0000-0002-3303-4819

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Ann Therese Bertagnolli · 2012 to 2026
$60.0M
Surveillance genome sequencing to detect SARS-CoV-2 virus variants in MontanaP30GM140963 · NIGMS · UNIVERSITY OF MONTANA · PI BOWLER, BRUCE E · 2021 to 2025
$6.9M
Structural and functional investigation of negative allosteric NMDA receptor modulationR01NS097536 · NINDS · UNIVERSITY OF MONTANA · PI Kasper Boe Hansen · 2016 to 2026
$3.4M
Physiology and pharmacology of GluN3-containing NMDA receptorsR01NS116055 · NINDS · UNIVERSITY OF MONTANA · PI HANSEN, KASPER BOE · 2021 to 2025
$1.8M
NIGMS NIH HHS P20 GM103474NIGMS NIH HHS P30 GM140963NINDS NIH HHS R01 NS097536NINDS NIH HHS R01 NS116055
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

allosteric modulationdrug discoveryIonotropic glutamate receptorsligand-gated ion channelsneuropharmacologysynaptic transmission

Identifiers

PMID41292873
PMCPMC12642611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.