ArticlebioRxiv : the preprint server for biology2025
Genotoxic formaldehyde and lipid aldehydes are sources of DNA damage in keratinocytes.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Aldehyde Detoxification in Cancer: Metabolic Guardians of the Genome.Biomolecules · 2026Review
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Authors and funding
4 authors.
Funding
Abstract
The Fanconi anemia (FA) pathway is vital for the repair of DNA interstrand crosslinks (ICLs), which are caused by a variety of endogenous and exogenous genotoxins including reactive aldehydes. Patients with pathogenic variants in the FA pathway are predisposed to early-onset, aggressive malignancies, especially leukemia and head and neck, esophageal, and anogenital squamous cell carcinomas (SCCs). Prior studies have linked endogenous formaldehyde and acetaldehyde in hematopoietic stem cells with bone marrow failure and leukemia in FA-deficient mice. However, the genotoxic aldehydes specific to mucosal keratinocytes, precursors of FA-associated SCCs, remain to be identified. Here, to identify alcohol dehydrogenases (ADHs) and aldehyde dehydrogenases (ALDHs) necessary for protection of keratinocyte genomes from endogenous metabolites, we used a sensitized background of FA-pathway deficiency. We systematically inactivated all highly expressed ADH and ALDHs genes in
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