Evidence map›Paper›PMID 41292820›Full record

ArticlebioRxiv : the preprint server for biology2025

The retinal light response is modulated by an mGluR5-mediated retrograde signal from ON-bipolar cells to photoreceptors.

Catherine W Morgans, Tammie L Haley, Gaoying Ren, Ian A M Taylor, Kate L Randall, Robert M Duvoisin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Catherine W MorgansDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, United States.
Tammie L HaleyDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, United States.
Gaoying RenDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, United States.
Ian A M TaylorDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, United States.
Kate L RandallDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, United States.
Robert M DuvoisinDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, United States.

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TED S ACOTT · 1995 to 2026
$19.4M
Molecular mechanisms of retinal ON-bipolar cell signalingR01EY029985 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI DUVOISIN, ROBERT M, MORGANS, CATHERINE W · 2019 to 2023
$2.6M
NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY029985
6 · The paper itself

Abstract

The ON visual pathway is initiated by the deactivation of mGluR6, coupled to the opening of TRPM1 channels in retinal ON-bipolar cell dendrites. Here, we show that a second metabotropic glutamate receptor, mGluR5, is localized with TRPM1 and mGluR6 in the dendrites of ON-bipolar cells. To examine the function of mGluR5, we performed electroretinogram (ERG) recordings and found that the amplitude of the b-wave, which is primarily a measure of ON-bipolar cell light-driven activity, is reduced in mGluR5 knock-out mice compared to wild type. In the mGluR5

Identifiers

PMID41292820
PMCPMC12642532

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.