Evidence map›Paper›PMID 41292813›Full record

ArticlebioRxiv : the preprint server for biology2025

SLC11A2 affects nutritional immunity in the gut epithelium.

Emilia S Norberg, Trina L Westerman, Eddy Cruz, Summer D Bushman, Eric P Skaar, Johanna R Elfenbein, Leigh A Knodler

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emilia S NorbergDepartment of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT.ORCID 0009-0007-7540-9301
Trina L WestermanDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Eddy CruzDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Summer D BushmanDepartment of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN.
Eric P SkaarDepartment of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN.
Johanna R ElfenbeinDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Leigh A KnodlerDepartment of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT.ORCID 0000-0002-3028-2198

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
A bacterial biosensor for intracellular metal availability in the gutR21AI166152 · NIAID · WASHINGTON STATE UNIVERSITY · PI KNODLER, LEIGH · 2022 to 2023
$449k
Differential regulation of three DMSO reductases during enteric salmonellosisF30AI169967 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Eddy Cruz · 2023 to 2026
$188k
Automated Tissue MicroarrayerS10OD023526 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MATKOWSKYJ, KRISTINA A. · 2018 to 2018
$184k
NCI NIH HHS P30 CA014520NIAID NIH HHS F30 AI169967NIAID NIH HHS R21 AI166152NIH HHS S10 OD023526
6 · The paper itself

Abstract

There is a constant tug-of-war for transition metals at the pathogen-host interface. A goal of the vertebrate host is to modulate the availability of metals to pathogens, in a process known as nutritional immunity, but pathogens have evolved numerous countermeasures to regulate intracellular trace metal levels. The bioavailability of trace metals therefore shapes the outcome of disease. In the human body, epithelial cells lining the intestine are a major site of metal absorption. Intestinal epithelial cells (IECs) are also a target for invading enteric pathogens but the contribution of epithelium-intrinsic factors towards nutritional immunity has been understudied. Using

Indexed as

Biological Sciencesenteric diseasegastrointestinal tractintestinal epithelial cellmetal homeostasisMicrobiologySalmonella enterica

Identifiers

PMID41292813
PMCPMC12642658

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.