Evidence map›Paper›PMID 41292760›Full record

ArticlebioRxiv : the preprint server for biology2025

The anticonvulsant and mood-stabilizing drug valproic acid attracts

Lucero E Rogel-Hernandez, Helena Casademunt, Aravinthan D T Samuel, Miriam B Goodman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lucero E Rogel-HernandezDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94304.ORCID 0000-0001-7361-0545
Helena CasademuntDepartment of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02134.ORCID 0000-0003-4644-2536
Aravinthan D T SamuelDepartment of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02134.ORCID 0000-0002-1672-8720
Miriam B GoodmanDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94304.ORCID 0000-0002-5810-1272

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stressR35NS105092 · NINDS · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B · 2018 to 2025
$6.4M
BRAIN CONNECTS: Rapid and Cost‐effective Connectomics with Intelligent Image Acquisition, Reconstruction, and QueryingU01NS132158 · NINDS · HARVARD UNIVERSITY · PI LICHTMAN, JEFF W, PFISTER, HANSPETER · 2023 to 2025
$4.3M
Molecular Pharmacology Training GrantT32GM113854 · NIGMS · STANFORD UNIVERSITY · PI MOCHLY-ROSEN, DARIA · 2015 to 2019
$1.1M
NIGMS NIH HHS T32 GM113854NIH HHS P40 OD010440NINDS NIH HHS R35 NS105092NINDS NIH HHS U01 NS132158
6 · The paper itself

Abstract

Valproic acid (VPA) is a drug with both anticonvulsant and antimanic properties. It has been widely prescribed to treat epilepsy, bipolar disorder, and other neuropsychiatric conditions for decades, but prenatal exposure is linked to developmental anomalies, cognitive deficits, and an increased risk of autism. Remarkably, the molecular basis of VPA action in the brain is not fully understood. To determine VPA's effect on the nervous system without requiring systemic drug application that induce toxic effects, we exploited the well-characterized chemotaxis behavior of the nematode

Identifiers

PMID41292760
PMCPMC12642618

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.