Evidence map›Paper›PMID 41292759›Full record

ArticlebioRxiv : the preprint server for biology2025

Polyclonal origins of human premalignant colorectal lesions.

Debra Van Egeren, Ryan O Schenck, Aziz Khan, Aaron M Horning, Shanlan Mo, Clemens L Weiß, Edward D Esplin, Winston R Becker, Si Wu, Casey Hanson and 32 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

42 authors.

Debra Van EgerenDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.ORCID 0000-0002-4017-0413
Ryan O SchenckDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Aziz KhanDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Aaron M HorningDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Shanlan MoKey Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Clemens L WeißDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Edward D EsplinDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Winston R BeckerDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Si WuDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Casey HansonDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Nasim BarapourDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Lihua JiangDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Kévin ContrepoisDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Hayan LeeDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Stephanie A NevinsDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Tuhin K GuhaDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Hao ZhangKey Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Zhen HeKey Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-sen University, Ministry of Education, Guangzhou, China.
Zhicheng MaDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Emma MonteDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Thomas V KarathanosDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Rozelle LaquindanumDepartment of Medicine, Stanford School of Medicine, Stanford, CA 94305.
Meredith A MillsDepartment of Medicine, Stanford School of Medicine, Stanford, CA 94305.
Hassan ChaibDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Roxanne ChiuDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Ruiqi JianDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Joanne ChanDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Mathew EllenbergerDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Bahareh BahmaniDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Basil MichaelDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Annika K WeimerDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
D Glen EsplinAnimal Reference Pathology, Salt Lake City, UT 84107.
Samuel LancasterDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Jeanne ShenDepartment of Pathology, Stanford School of Medicine, Stanford, CA 94305.
Uri LadabaumDepartment of Medicine, Stanford School of Medicine, Stanford, CA 94305.
Teri A LongacreDepartment of Pathology, Stanford School of Medicine, Stanford, CA 94305.
Anshul KundajeDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
William J GreenleafDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Zheng HuDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
James M FordDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Michael P SnyderDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.
Christina CurtisDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305.ORCID 0000-0003-0166-3802

Funding

PreCancer Atlas of Familial Adenomatous PolyposisU2CCA233311 · NCI · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2018 to 2023
$11.6M
Forecasting tumor evolution: can the past reveal the future?DP1CA238296 · NCI · STANFORD UNIVERSITY · PI CURTIS, CHRISTINA N · 2018 to 2022
$5.5M
Cancer Systems Biology Scholars ProgramR25CA180993 · NCI · STANFORD UNIVERSITY · PI PLEVRITIS, SYLVIA KATINA · 2014 to 2018
$2.2M
Ultra high throughput sequencer for sustaining and enhancing multi-scale genomic studiesS10OD025212 · OD · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2018 to 2018
$600k
NCI NIH HHS DP1 CA238296NCI NIH HHS R25 CA180993NCI NIH HHS U2C CA233311NIH HHS S10 OD025212
6 · The paper itself

Abstract

Cancer is generally thought to be caused by expansion of a single mutant cell

Identifiers

PMID41292759
PMCPMC12642608

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.