Evidence map›Paper›PMID 41292723›Full record

ArticlebioRxiv : the preprint server for biology2025

Employing RNA editing to engineer personalized tumor-specific neoantigens (editopes).

Riccardo Pecori, Beatrice Casati, Rona Merdler-Rabinowicz, Netanel Landesman, Khwab Sanghvi, Stefan Zens, Kai Kipfstuhl, Veronica Pinamonti, Annette Arnold, John M Lindner and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Riccardo PecoriDivision of Immune Diversity, German Cancer Research Centre (DKFZ), Heidelberg, 69120, Germany.ORCID 0000-0001-9052-4075
Beatrice CasatiDivision of Immune Diversity, German Cancer Research Centre (DKFZ), Heidelberg, 69120, Germany.ORCID 0000-0001-8516-5792
Rona Merdler-RabinowiczCancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.
Netanel LandesmanMina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
Khwab SanghviDivision of Neuroimmunology and Brain Tumor Immunology, German Cancer Research Centre (DKFZ), Heidelberg, 69120, Germany.
Stefan ZensDivision of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Centre (DKFZ), Heidelberg, 69120, Germany.
Kai KipfstuhlDivision of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Centre (DKFZ), Heidelberg, 69120, Germany.
Veronica PinamontiFaculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0001-5253-095X
Annette ArnoldDivision of Immune Diversity, German Cancer Research Centre (DKFZ), Heidelberg, 69120, Germany.
John M LindnerBioMed X Institute, 69120 Heidelberg, Germany.ORCID 0000-0002-4940-5354
Michael PlattenDivision of Neuroimmunology and Brain Tumor Immunology, German Cancer Research Centre (DKFZ), Heidelberg, 69120, Germany.
Rienk OffringaDivision of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Centre (DKFZ), Heidelberg, 69120, Germany.
Rafael CarreteroDivision of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Centre (DKFZ), Heidelberg, 69120, Germany.
Eytan RuppinCancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.
Erez Y LevanonMina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
Fotini Nina PapavasiliouDivision of Immune Diversity, German Cancer Research Centre (DKFZ), Heidelberg, 69120, Germany.ORCID 0000-0002-5971-7909

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing the quantity and immunogenicity of neoantigens in tumors is essential for advancing immunotherapy. However, engineering neoantigens remains challenging due to the need for precise, tumor-specific antigen modification without affecting normal cells. To tackle this challenge, we developed

Identifiers

PMID41292723
PMCPMC12642233

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.