Evidence map›Paper›PMID 41292721›Full record

ArticlebioRxiv : the preprint server for biology2025

Stress granules and protein aggregates reveal intracellular resource competition.

Hannah E Buchholz, Sean A Martin, Jane E Dorweiler, Derek C Prosser, Emily M Sontag, Anita L Manogaran

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hannah E BuchholzDepartment of Biological Sciences, Marquette University, Milwaukee, WI, 53201-1881 USA.
Sean A MartinDepartment of Biological Sciences, Marquette University, Milwaukee, WI, 53201-1881 USA.
Jane E DorweilerDepartment of Biological Sciences, Marquette University, Milwaukee, WI, 53201-1881 USA.
Derek C ProsserSchool of Life Sciences and Sustainability, Virginia Commonwealth University, Richmond, VA, 23284-2012 USA.
Emily M SontagDepartment of Biological Sciences, Marquette University, Milwaukee, WI, 53201-1881 USA.
Anita L ManogaranDepartment of Biological Sciences, Marquette University, Milwaukee, WI, 53201-1881 USA.ORCID 0000-0003-0844-1479

Funding

Understanding the role of molecular chaperone systems in protein aggregate disassemblyR15GM155860 · NIGMS · MARQUETTE UNIVERSITY · PI MANOGARAN, ANITA L. · 2024 to 2024
$459k
NIGMS NIH HHS R15 GM155860
6 · The paper itself

Abstract

Stress granules are biomolecular condensates that form in response to environmental stress and disassemble once normal conditions are restored. However, when disassembly fails, stress granules can persist and solidify. While stress granule solidification has been well documented, the cellular mechanisms underlying the transition from reversible to persistent stress granules remain unclear. Persistent stress granules can seed the formation of pathological aggregates, such as TDP-43 in amyotrophic lateral sclerosis

Identifiers

PMID41292721
PMCPMC12642510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.