ArticleResearch (Washington, D.C.)2025
BBB-Crossing Ionizable Upconversion Nanoparticles for Synergistic Therapy of Carbapenem-Resistant Central Nervous System Infection.
Article in Research (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Orally activatable membrane fusion-mitochondria hitchhiking on intestinal macrophages for targeted therapy of bacterial meningitis and neuroinflammation.Bioactive materials · 2027Article
- Role of Pattern Recognition Receptors (PRRs) in Spinal Cord Injury (SCI): A Comprehensive Review.Molecular neurobiology · 2026Review
- Aptamer-guided upconversion nanoconstructs enable proximity-dependent and precise photodynamic therapy for MRSA-infected wounds.Materials today. Bio · 2026Article
- Effective plasmonic enhancement of up-conversion photoluminescence from α-NaGdFScientific reports · 2026Article
- Preparation Method of Upconversion Nanoparticles and Its Biological Application.Nanomaterials (Basel, Switzerland) · 2026Review
- Ag-CuO Nanozymes Superior to Commercial Silver-Based Dressings: Synergistic Antibacterial Therapy via PTS-Mediated Starvation and Cuproptosis-Like Death.Research (Washington, D.C.) · 2026Article
- Pitaya‑inspired compartmentalized microspheres with natural tannic acid-copper coating orchestrate smart release of ions and multi-drugs for synergistic treatment of infected bone defects.Regenerative biomaterials · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central nervous system (CNS) infections caused by carbapenem-resistant Enterobacteriaceae (CRE) biofilms pose a major critical healthcare challenge. These infections are difficult to treat due to the rising prevalence of antibiotic resistance and the restrictive nature of the blood-brain barrier (BBB), which limits therapeutic access to the brain tissue. To address this, we developed an innovative pH-responsive nanotherapeutic platform, UC@MOF@RB+MEM, integrating upconversion nanoparticles (UCNPs), a metal-organic framework (MOF), the photosensitizer rose bengal (RB), and the antibiotic meropenem (MEM). This design exhibited dual responsiveness to both pH and near-infrared (NIR) light, creating synergistic effects that disrupted biofilm and eradicated bacteria while mitigating neuroinflammation. During CNS inflammation, BBB permeability increased, enabling the ionizable UC@MOF@RB+MEM nanoparticles to cross the BBB and target infection sites. In the acidic microenvironment of the infection, these nanoparticles released MEM, RB, and Zn
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.