Evidence map›Paper›PMID 41292702›Full record

ArticleResearch (Washington, D.C.)2025

FGF2 Attenuated Inflammation-Mediated Cardiac Damage: A Novel Mechanistic Insight into the AMPK-FUNDC1-Mitophagy.

Pingjun Zhu, Xi Wang, Xinjie Han, Yan Wang, Yongkai Ding, Min Zhu, Xin Zhang, Qian Xu, Yukun Li, Zhongxuan Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Pingjun ZhuThe Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Xi WangThe Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Xinjie HanThe Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Yan WangDepartment of Emergency, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing 102218, China.
Yongkai DingThe Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Min ZhuThe Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Xin ZhangThe Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Qian XuThe Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Yukun LiDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Zhongxuan LiChinese PLA General Hospital, Medical School of Chinese PLA, Beijing 100853, China.
Zhi LuDepartment of Automation & Institute for Brain and Cognitive Sciences, Tsinghua University, Beijing 100084, China.
Qi ZhangDepartment of Automation & Institute for Brain and Cognitive Sciences, Tsinghua University, Beijing 100084, China.
Yan YinDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Guogang XuThe Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.ORCID https://orcid.org/0000-0002-6380-3500
Yingzhen DuThe Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Septic cardiomyopathy, a severe complication of sepsis, is characterized by high morbidity and mortality rates, and its effective management remains an important challenge. Although fibroblast growth factor 2 (FGF2) has been shown to exert cardioprotective effects, its role in septic cardiomyopathy has not been extensively investigated. To address this knowledge gap, FGF2 knockout (FGF2

Identifiers

PMID41292702
PMCPMC12641185

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.