Evidence map›Paper›PMID 41292688›Full record

ArticleFrontiers in microbiology2025

Caffeine restricts hepatitis B virus transcription by inhibiting

Fangli Liao, Siyi Sun, Wenjuan Huang, Liping Yang, Qin Hu, Weixian Chen, Chaolin Tu, Linshan Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fangli Liao *Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Siyi Sun *Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wenjuan Huang *Department of Laboratory Medicine, Chongqing Orthopedic Hospital of Traditional Chinese Medicine, Chongqing, China.
Liping YangDepartment of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qin HuDepartment of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Weixian ChenDepartment of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chaolin TuDepartment of Laboratory Medicine, Chongqing University Three Gorges Hospital, Chongqing University, Chongqing, China.
Linshan JiangDepartment of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The influence of caffeine on human health has been widely studied, but its relevance to hepatitis B virus (HBV) remains unclear. Here, we report that exogenous caffeine suppresses HBV RNA and core protein expression in hepatoma cells. Mechanistically, caffeine reduces the DNA damage marker

Indexed as

caffeinecore promoternutritional interventionPPARαγ-H2AX

Identifiers

PMID41292688
PMCPMC12640983

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.