ArticleFood science & nutrition2025
Vitamin C Supplementation During Intensive Care Unit Stay Is Associated With Improved Outcomes in Critically Ill Patients With Sepsis-Induced Coagulopathy: A Cohort Study.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Trends and Core Competence Shifts in Nurses' Infectious Disease Emergency Response Competence Across COVID-19 Pandemic Phases: Repeated Cross-Sectional Survey and Network Analysis.JMIR public health and surveillance · 2026Article
- Vitamin C Supplementation During Intensive Care Unit Stay Is Associated With Improved Outcomes in Critically Ill Patients With Sepsis-Induced Coagulopathy: A Cohort Study.Food science & nutrition · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate whether vitamin C provides survival benefit in critically ill patients with sepsis-induced coagulopathy (SIC). Patients with SIC admitted to the ICU were identified from the Medical Information Mart for Intensive Care (MIMIC)-IV database. The exposure factor was vitamin C supplementation during the ICU stay. The primary outcome was 28-day all-cause mortality, the secondary outcome was 60-day all-cause mortality, in-ICU mortality, and the extended outcomes included duration of mechanical ventilation, ICU stay, and hospital stay. Both propensity score matching (PSM) and multivariable Cox models were employed to adjust for potential confounders. Sensitivity analyses and subgroup assessments were also performed to verify the study findings. A total of 18,283 eligible patients were enrolled in the entire unmatched cohort, and 2251 patients were included in the matched cohort. In PSM analysis, vitamin C supplementation was associated with decreased 28-day all-cause mortality (HR, 0.52; 95% CI, 0.40-0.69;
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