ArticlemedRxiv : the preprint server for health sciences2025
Impact of Genetic Risk Factors on Coronary Heart Disease Risk Across the Age Spectrum in Three Major Race/Ethnicity Groups in the United States.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Measures of genetic predisposition can improve prediction of risk of cardiometabolic diseases but more data is needed in groups under-represented in genomics research. In this study, we investigated the impact of genetic risk factors for coronary heart disease (CHD) - polygenic risk, monogenic risk [in the form of familial hypercholesterolemia (FH)], and family history (FamHx) - on CHD risk estimates, across the age spectrum, in two diverse cohorts of US adults - eMERGE IV (eIV) and Methods: CHD was defined as myocardial infarction, unstable angina, and coronary revascularization. Self-identified race/ethnicity (SIRE) was used as a population descriptor. We calculated a polygenic risk score for CHD (PRS Results: We analyzed data for 19,348 participants from eIV (age 50.6±15.0, 68% female, 40.5% non-White) and 239,645 participants from AoU (age 55.4±17.0, 60.6% female, 48% non-White). The effects of PRS Conclusion: PRS
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