Evidence map›Paper›PMID 41292630›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Adaptive nuclear GTP synthesis promotes glioblastoma treatment resistance and is a targetable vulnerability in patients.

Andrew J Scott, Ningning Liang, Wajd N Al-Holou, Jie Xu, Alexandra O'Brien, Angelica Lin, Vidhi Pareek, Zhou Sha, Zitong Zhao, John Z Yang and 30 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Andrew J ScottDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Ningning LiangDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Wajd N Al-HolouRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Jie XuDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Alexandra O'BrienDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Angelica LinDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Vidhi PareekDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.
Zhou ShaDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.
Zitong ZhaoDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
John Z YangDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Annabel YangDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Ayesha U KothariDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Kari Wilder-RomansDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Zhe WuDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Jiane FengDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Navyateja KorimerlaDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Ameer ElaimyDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Sravya PalavalasaDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Jiali ChenBiology Department, University of San Francisco, San Francisco, CA, USA.
Lu WangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Li ZhangDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Anthony C AndrenDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Peter SajjakulnukitDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Bernard MariniDepartment of Pharmacy Services and Clinical Pharmacy, Michigan Medicine, Ann Arbor, MI, USA.
Jason A HethDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Meredith A MorganDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Theodore S LawrenceDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Stephen J BenkovicDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.
Deepak NagrathDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Sriram ChandrasekaranRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Nathan R QiDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Duxin SunDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Bo WenDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Manjunath P PaiUniversity of Michigan College of Pharmacy, Ann Arbor, MI, USA.
Nathan ClarkeDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Krithika SureshDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Yoshie UmemuraDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Costas A LyssiotisRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Weihua ZhouDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Daniel R WahlDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.

Funding

Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John D. Meeker · 2011 to 2026
$21.3M
Translational Pathology CoreP50CA269022 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE, Meredith A Morgan · 2023 to 2026
$10.0M
Training Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3M
TRANSFORMYLASE ENZYMES--DIHYDROFOLATE REDUCTASER01GM024129 · NIGMS · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI BENKOVIC, STEPHEN J · 1985 to 2024
$5.2M
Metabolic Phenotyping in Live Models of Obesity and DiabetesU2CDK135066 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias · 2023 to 2026
$3.5M
Defining Tumor Microenvironmental Interactions that drive THY1-Mediated Treatment Resistance in GlioblastomaK08NS128271 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Wajd Al-Holou · 2024 to 2026
$700k
Defining and interrupting metabolic crosstalk in the glioblastoma microenvironmentK99CA300923 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Andrew Joseph Scott · 2025 to 2026
$273k
Targeting purine biosynthesis to radiosensitize glioblastomaF32CA260735 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT, ANDREW JOSEPH · 2021 to 2023
$185k
NCI NIH HHS F32 CA260735NCI NIH HHS K99 CA300923NCI NIH HHS P50 CA269022NCI NIH HHS T32 CA009676NIDDK NIH HHS U2C DK135066NIEHS NIH HHS P30 ES017885NIGMS NIH HHS R01 GM024129NINDS NIH HHS K08 NS128271
6 · The paper itself

Abstract

Glioblastoma (GBM), the most lethal of all brain cancers, resists therapy by rewiring metabolism and relying on GTP signaling to promote DNA repair and radiation therapy (RT) resistance. How GBM modulates GTP levels for this signaling in response to RT-induced DNA damage, and the therapeutic tractability of this metabolic activity in the context of standard-of-care chemoradiation therapy, remain unaddressed. Here, we identify acute changes in glioma metabolism within hours of RT, including an acute post-RT rewiring of guanylate synthesis driven by nuclear translocation of the rate-limiting

Identifiers

PMID41292630
PMCPMC12642738

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.