Evidence map›Paper›PMID 41292522›Full record

ArticleMediators of inflammation2025

Association of Immune Cells, Inflammatory Cytokines, and Lung Cancer: A Mediating Mendelian Randomization Study.

Lang Li, Ying Zhu, Chenchong Zhao, Yinuo Tangwu, Lvyuan He, Gaochen Lan

Abstract read
In one paragraph

Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lang LiDepartment of Hematology, Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, 438 West Shuangxi Road, Jinhua 321017, China.ORCID https://orcid.org/0000-0002-2946-7021
Ying ZhuDepartment of Hematology, Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, 438 West Shuangxi Road, Jinhua 321017, China.
Chenchong ZhaoDepartment of Pneumology, Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, 438 West Shuangxi Road, Jinhua 321017, China.
Yinuo TangwuDepartment of Pneumology, Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, 438 West Shuangxi Road, Jinhua 321017, China.ORCID https://orcid.org/0000-0002-4149-636X
Lvyuan HeDepartment of Hematology, Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, 438 West Shuangxi Road, Jinhua 321017, China.ORCID https://orcid.org/0009-0004-0514-1686
Gaochen LanDepartment of Oncology, The Second Affiliated Hospital of Fujian Medical University, 950 Donghai Street, Quanzhou 362018, Fujian, China.ORCID https://orcid.org/0009-0001-9324-931X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lung cancer oncogenesis involves interactions between immune cells and inflammatory cytokines. However, their causal relationships and mediating mechanism remain unclear. Methods: Using a mediating Mendelian randomization (MR) approach, we analyzed genome-wide association study (GWAS) data for 731 immune-cellular phenotypes, 41 cytokines, and eight related lung cancer phenotypes. Results: Conclusions: These findings reveal the associations between immune cells, inflammatory cytokines, and lung cancer risk, providing insights into cancer diagnosis and treatment.

Indexed as

CytokinesLung NeoplasmsMendelian Randomization AnalysisB-LymphocytesGenome-Wide Association StudyHumansInterleukin-2Interleukin-6CytokinesInterleukin-2Interleukin-6causal relationshipimmune cellinflammatory cytokinelung cancermendelian randomization

Identifiers

PMID41292522
PMCPMC12643680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.