Evidence map›Paper›PMID 41292504›Full record

ReviewFuture cardiology2025

Cross-pollination of two specialties: potential repurposing of cancer and cardiovascular drugs for the benefit of the other.

Orly Leiva, Jeanne M DeCara, Eric H Yang, Leo Gozdecki, Anthony Kanelidis, Stanley Swat

Abstract readReview
In one paragraph

Review in Future cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Orly LeivaGill Heart & Vascular Institute, University of Kentucky, Lexington, KY, USA.
Jeanne M DeCaraSection of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Eric H YangUCLA Cardio-Oncology Program, Division of Cardiology, Department of Medicine, University of California, Los Angeles, CA, USA.
Leo GozdeckiSection of Cardiology - Heart Failure, Department of Medicine, University of Chicago, Chicago, IL, USA.
Anthony KanelidisSection of Cardiology - Heart Failure, Department of Medicine, University of Chicago, Chicago, IL, USA.
Stanley SwatSection of Cardiology - Heart Failure, Department of Medicine, University of Chicago, Chicago, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite advancements in treatment, cancer and cardiovascular disease remain the leading causes of morbidity and mortality in developed nations. Cancer therapies have led to improved cancer-specific outcomes at the potential risk of cardiotoxicity. Additionally, basic and translational research have demonstrated a common shared pathophysiology of cancer and cardiovascular disease. Recent clinical research has suggested a potential role of repurposing cancer and cardiovascular medications for the treatment of each other. This narrative review aims to review and examine current literature of repurposing cancer and cardiovascular drugs via exploitation of off-target effects to benefit each condition. A better understanding of underlying pathophysiologic effects of these off-target mechanisms of action may aid in identifying novel therapeutics for both cancer and cardiovascular disease.

Indexed as

Antineoplastic AgentsCardiovascular AgentsCardiovascular DiseasesDrug RepositioningNeoplasmsCardiotoxicityHumansAntineoplastic AgentsCardiovascular Agentsanti-platelet agentsatherosclerosisCardiomyopathiesheart failurethrombosis

Identifiers

PMID41292504
PMCPMC12758306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.