Evidence map›Paper›PMID 41292365›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Influence of Rare Earth Elements on Prebiotic Reaction Networks Resembling the Biologically Relevant Krebs Cycle.

Jonathan Gutenthaler-Tietze, Carolina G Heßler, Lena J Daumann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jonathan Gutenthaler-TietzeChair of Bioinorganic Chemistry, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany.
Carolina G HeßlerChair of Bioinorganic Chemistry, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany.
Lena J DaumannChair of Bioinorganic Chemistry, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany.ORCID 0000-0003-2197-136X

Funding

Deutsche Forschungsgemeinschaft SFB1309-325871075Deutsche Forschungsgemeinschaft SFB1573-471424360
6 · The paper itself

Abstract

Rare earth elements (REEs) are not rare, but rather abundant in the earth's crust and excellent catalysts for a multitude of organic reactions. They have been recently shown to be used in the active sites of bacterial enzymes and thus essential for metabolic processes. However, these elements have so far been disregarded with respect to their possible contributions to the emergence of complex molecules. Here, we investigate the potential of REEs to act as mediators in a prebiotic reaction network resembling the biological Krebs cycle starting from glyoxylate and pyruvate. Special focus is put on a comparison between trivalent REEs and ferrous iron. Reaction products were analyzed by gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR) spectroscopy. Contrary to Fe

Indexed as

Citric Acid CycleMetals, Rare EarthGas Chromatography-Mass SpectrometryGlyoxylatesMagnetic Resonance SpectroscopyPyruvic AcidGlyoxylatesglyoxylic acidMetals, Rare EarthPyruvic AcidKrebs cycleLanthanidesOriginsPrebiotic reaction networksRare earth elements

Identifiers

PMID41292365
PMCPMC12828449

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.